Program

Thursday March 28th
12.00-18.00Arrival of participants
18.00-19.00Welcome drinks
19.00-20.15Scientific Session 1
Chairs: Eleni Frangou and Moe Daha
19.00-19.15Welcome from the Organizing Committee
19.15-19.45First plenary talk
Christos Chatziantoniou
Historical landmarks
19.45-20.15Second plenary talk
Hans-Joachim Anders
Exploring crystal-induced kidney diseases
20.30-22.00 Dinner
Friday March 29th
07.00-08.30Breakfast
08.30-10.30Scientific Session 2
Diabetic nephropathy and related conditions
Chairs: Miriam Banas and Marc Dockrel
08.30-09.00Third plenary talk
Christian Kurts
Dendritic cells in kidney inflammation and consequences for progression of renal disease
09.00-10.30Abstract presentations
09.00-09.15
A new SHIP2 inhibitor enhances insulin sensitivity and attenuates kidney injury in diabetic db/db mice
Zydrune Polianskyte-Prause1, Tuomas A. Tolvanen2, Sonja Lindfors1, Kanta Kon3, Laura C. Hautala1, Hong Wang2, Vincent Dumont1, Tsutomu Wada3, Hiroshi Tsuneki3, Toshiyasu Sasaoka3, Sanna Lehtonen1,2


1Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland;
2 Department of Pathology, University of Helsinki, Helsinki, Finland;
3 Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

09.15-09.30
Secreted condition media from human amniotic fluid mesenchymal stem cells ameliorate podocyte injury in isolated diabetic rat glomeruli.
Trohatou O.1, Mantsiou A.2, Makridakis M.2, Vlahou A.2, Charonis A.3, Roubelakis M,4,5 and Drossopoulou G1


1 Institute of Biosciences and Applications, NCSR “Demokritos”, Athens, Greece
2 Center for Systems Biology, Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece.
3 Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece
4 Laboratory of Biology, Department of Basic Medical Sciences, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
5 Center of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece

09.30-09.45
Delineation of Specific Pathways Involved in SGLT2 Mediated Fibrosis in a Cellular Model of Diabetic Kidney Disease
Xinlu Pan1, Deborah L. Baines3, Mysore K. Phanish1,2, Mark E. Dockrell1,3


1 SWT Institute for Renal Research, London,
2 Epsom and St Helier University Hospitals NHS Trust, London,
3 St George’s, University of London, London, United Kingdom.

09.45-10.00
NEAT1 as novel player in diabetic nephropathy
Simone Reichelt-Wurm1, Tobias Wirtz1, Matthias Pregler1, Lena Knauss1, Markus Kretz2, Bernhard Banas1, Miriam C. Banas1


1 Department of Nephrology, University Hospital of Regensburg, Regensburg, Germany
2 Institute of Biochemistry, University of Regensburg, Regensburg, Germany

10.00-10.15
Relationships between biochemical mineral metabolism parameters and anemia in non-dialysis chronic kidney disease patients
C Capusa1,2, C Chiriac1, A-M Mehedinti1,2, A Stanciu2, M Lipan2, G Mircescu1,2


1 Nephrology Dept., “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2
“Dr Carol Davila” Teaching Hospital of Nephrology, Bucharest, Romania

10.15-10.30
Hypertensive Nephrosclerosis: In search of biomarkers for early damage
G. Barkas1,2, A. Hatziioannou1, J. Zoidakis1, M. Makridakis1, A. Vlahou1, A. Charonis1, D.V.Vlahakos1,2


1 Biomedical Research Foundation of the Academy of Athens
2 National and Kapodistrian University of Athens Medical School, Athens, Greece

10.30-11.00Coffee Break
11.00-13.00Scientific Session 3
Renal diseases
Chairs: Madeline Murphy and Roel Goldscmeding
11.00-11.30Fourth plenary talk
Dimitris Boumpas
Recent -omics approaches in lupus nephritis
11.30-13.00Abstract presentations
11.30-11.45
The REDD1/autophagy pathway mediates the release of TF- and IL-17A-bearing Neutrophil Extracellular Traps (NETs) in human Systemic Lupus Erythematosus (SLE), promoting thromboinflammation and fibrosis
Eleni Frangou1,2,3, Akrivi Chrysanthopoulou4, Konstantinos Kambas4, Alexandros Mitsios4, Stella Arelaki4, Iliana Angelidou4, Thanos Arambatzioglou4, Chara Gakiopoulou5, George Bertsias6, Panayotis Verginis3, Konstantinos Ritis4, Dimitrios T. Boumpas2,3,7,8


1 Department of Nephrology, Limassol General Hospital, Limassol, Cyprus;
2
Medical School, University of Cyprus, Nicosia, Cyprus;
3
Biomedical Research Foundation of the Academy of Athens, Athens, Greece;
4
Medical School, Democritus University of Thrace, Alexandroupolis, Greece;
5
Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece;
6
Rheumatology, Clinical Immunology and Allergy, University of Crete School of Medicine, Heraklion, Greece;
7
4th Department of Medicine, “Attikon” University Hospital, Athens, Greece;
8
Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece

11.45-12.00
Differentiation promoting therapy inhibits dis-regulated renal progenitor proliferation in an experimental model of rapidly progressive glomerulonephritis
Maria Elena Melica1,3, Letizia De Chiara1,3, Elena Lazzeri1,3, Maria Lucia Angelotti1,3, Carolina Conte1,3, Anna Peired1,3, Giulia Antonelli1,3, Benedetta Mazzinghi1,3, Laura Lasagni 1,3, Paola Romagnani 1,2,3


1 Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy,
2 Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence, Italy,
3
Excellence Center DENOTHE, University of Florence, Florence, Italy

12.00-12.15
Autosomic dominant transmission of osseous metaplasia of the kidney
Yousfi N1, Piccoli G2, Mandich P3, Debiec H1, Ronco P1


1 Inserm UMR_S 1155, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France
2
Department of Clinical and Biological Sciences, University of Torino, Torino, Italy
3
Department of Genetics University of Genova, Italy

12.15-12.30
Is periostin a useful biomarker for assessing prognosis in primary glomerulopathies?
Nicolae Pană1,2, Gabriel Mircescu1,2, Cristina Căpușă1,2


1 “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2
“Dr Carol Davila” Teaching Hospital of Nephrology, Bucharest, Romania

12.30-12.45
Sphingosine 1-phosphate in renal diseases
Timon Eckes1, Josef Pfeilschifter1, Alexander Koch1


1 Department of General Pharmacology and Toxicology, Goethe University and University Hospital Frankfurt, D-60590 Frankfurt am Main, Germany

12.45-13.15Free time
13.15-14.30 Lunch
14.30-16.00Free time
16.00-18.00Scientific Session 4
AKI – Tubular cells
Chairs: Elena Lazzeri and Panos Politis
16.00-16.30Fifth plenary talk
Paola RomagnianiKidney repair: mechanisms and trade-off
16.30-18.00Abstract presentations
16.30-16.45
Endocycle is essential to survive Acute Kidney Injury but it contributes to Chronic Kidney Disease development
Letizia De Chiara1,3, Elena Lazzeri1,3, Maria Lucia Angelotti1,3, Carolina Conte1,3, Anna Peired1,3, Giulia Antonelli1,3, Maria Elena Melica1,3, Marco Allinovi12,,3, Benedetta Mazzinghi1,3, Laura Lasagni1,3, Paola Romagnani1,2,3


1 Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy,
2 Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence, Italy,
3 Excellence Center DENOTHE, University of Florence, Florence, Italy

16.45-17.00
Periostin promotes cell regeneration and macrophage polarization to drive renal repair in Ischemia/Reperfusion-induced Acute Kidney Injury
Niki Prakoura1, Raphaёl Kormann1,2, Panagiotis Kavvadas1, Sandrine Placier1, Aude Dorison1,2, Jean-Claude Dussaule1,2, Christos Chadjichristos1,2, Christos Chatziantoniou1,2


1INSERM UMRS 1155, Tenon Hospital, Paris, France;
2Sorbonne Université, Paris, France.

17.00-17.15
Tubular STAT5 drives a protective signaling during cisplatin-induced nephropathy
Aymeric Couturier1, Aïssata Niasse1, Helene Dobosziewicz1, Perrine Frere1, Sandrine Placier1, Yi-Chun Xu-Dubois1, Sophie Vandermeersch1, Anthony Corchia1, Lothar Hennighausen2, Eric Rondeau3, Mesnard Laurent3, Yosu Luque3


1 Inserm umrs1155, Tenon Hospital AP-HP, Paris, France
2 Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, United States of America
3 Service de Néphrologie et Transplantation Rénale, Hopital Tenon, Paris,France

17.15-17.30
Tryptophan deprivation preconditioning protects human renal epithelial cells against endoplasmic reticulum stress-induced apoptosis through autophagy
Georgios Pissas1, Theodoros Eleftheriadis1, Maria Tziastoudi2, Eleni Karamitrou1, Ioannis Stefanidis1


1 Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece,
2
Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece

17.30-17.45
Calcineurin inhibitors do not deregulate subcellular reactive oxygen species content at physiological concentrations
Yasaman Ramazani1, Celien Lismont2, Ahmed Reda1, Fanny Oliveira Arcolino1, Noel Knops1, Bert van den Heuvel1, Dirk Kuypers3, Marc Fransen2, Elena Levtchenko1


1 Laboratory of Pediatric Nephrology, University of Leuven (KU Leuven), Belgium
2
Laboratory of Lipid Biochemistry and Protein Interactions, University of Leuven (KU Leuven), Belgium
3
Laboratory of Nephrology, University of Leuven (KU Leuven), and University Hospital Leuven (UZ Leuven)

17.45-18.00
ANKHD1 enhances polycystic kidney disease via altering proliferative pathways in a mouse model of autosomal dominant polycystic kidney disease.
Maria Fragiadaki1, Albert Ong1, Martin Zeidler2


1 Department of Infection, Immunity and cardiovascular Disease, University of Sheffield, UK.
2 Department of Biomedical Science, University of Sheffield, UK.

18.00-18.30 Coffee Break
18.30-20.00Scientific Session 5
Signaling – Receptors
Chairs: Debra Higgins and Christos Chadjichristos
18.30-20.00Abstract presentations
18.30-18.45
MAPK activity regulates kidney size and nephron number via multiple cellular functions
Anneliis Ihermann1,2, Kristen Kurtzeborn1,2, Huyk Nam Kwon1,2, Hao Li1,2, Satu Kuure1,2,3


1 Stem Cells and Metabolism Research Program and Medicum, Faculty of Medicine,
2 Helsinki Institute of Life Science,
3
GM-unit, University of Helsinki

18.45-19.00
Renin cells with defective Gsα/cAMP-signaling are involved in the development of renal endothelial damage
Anne Steglich, Friederike Kessel, Michael Gerlach, Christian Hugo, Vladimir T. Todorov


Experimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus, TU Dresden

19.00-19.15
A Novel, Fast Albuminuric Mouse Model Detects Kidney Protection of Soluble Guanylate Cyclase (sGC) Modulators
Simone Romoli1,2, Karoline Dröbner1, Frank Eitner1


1 Cardiovascular Research II, Preclinical Research, Bayer AG, Wuppertal, Germany
2
Cardiovascular, Renal and Metabolism, MedImmune, Cambridge, UK

19.15-19.30
Cold shock proteins interfere with TNFα binding to its receptor and modulate progranulin-mediated inhibition of signaling
Josephine Hildebrandt1, Christopher Hessman1, Antonia Bock1, Sabine Brandt1, Björn Frye1, Ute Raffetseder1, Robert Geffers1, Peter R. Mertens1, Jonathan A. Lindquist1


1 Clinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany,
2 Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany,
3 Genome Analytics Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

19.30-19.45 The differential effect of the cannabinoid receptor type 1 in various murine experimental models of nephropathy Myriam Dao1,2, Mélanie Ferreira1, Jade Colin1, Sandrine Placier1, Sophie Vandermeersch1, Liliane Louedec1, Christos Chatziantoniou1, Hélène François1,3


1 Unité Inserm 1155, Hôpital Tenon, Paris, France 2 Service de Néphrologie Adulte, Hôpital Necker, Paris, France 3 Service d’Urgence Néphrologique et de Transplantation rénale, Hôpital Tenon, Paris, France

19.45-20.00 Membrane-bound Klotho does not play a significant role in podocyte biology Emmanuelle Charrin1, Rik Mencke2, Dina Dabaghie1, Sonia Zambrano Sevilla1, Hannes Olauson3 and Jaakko Patrakka1


1 Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Center, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden;
2
Division of Pathology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;

3
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

19.45-20.30Free time
20.30-22.00 Dinner
Saturday March 30th
07.00-08.30Breakfast
08.30-10.30Scientific Session 6
08.30-09.00Sixth plenary talk
Jaako Patrakka
High throughput RNA profiling of the glomerulus – novel insights into biology and diseases of the kidney filter
09.00-10.30Abstract presentations
09.00-09.15
What is the crucial challenge to podocytes that prevents their proliferation?
Wilhelm Kriz


Department of Neuroanatomy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

09.15-09.30
Pax2a is upregulated in podocytes in a zebrafish injury model
Sophie Daniel1, Florian Siegerist1, Weibin Zhou2, Karlhans Endlich1, Nicole Endlich1


1 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany
2
Department of Pediatrics and Communicable Diseases and Human Genetics, Ann Arbor, Michigan, USA

09.30-09.45
3D-structured illumination microscopy reveals increased Claudin-5 localization to the filtration slit in effaced podocyte foot processes
Florian Teschd1 , Florian Siegerist1 , Nadine Artelt1 , Kerstin Amann2 , Uwe Zimmermann3 , Christos Chatziantoniou4 , Karlhans Endlich1 , Nicole Endlich1


1 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany
2 Department of Nephropathology, Institute of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany
3 Department of Urology, University Medicine Greifswald, Greifswald, Germany
4 National Institute for Health and Medical Research (INSERM), Unité Mixte de Recherche (UMR)-S1155, Tenon Hospital, Sorbonne Universités, Paris, France

09.45-10.00
EPAC1-mediated cAMP signaling delays progression of experimental glomerulonephritis
Kavvadas P1, Laudette M2, Prakoura N1, Chadjichristos C1, De Sousa Jorge A1, Lezoualc’h F2, Chatziantoniou C1


1 INSERM UMRS 1155, Tenon Hospital, Sorbonne Universite, Paris, France
2 INSERM UMRS 1048, Université de Toulouse III Paul Sabatier, Toulouse, France

10.00-10.15
Human Parietal Epithelial Cells (PECs) express ClC-5, megalin and cubilin in vivo
Lisa Gianesello1, Monica Ceol1, Hernán Trimarchi2, Giovanna Priante1, Annalisa Angelini3, Marny Fedrigo3, Alejandro Iotti4, Franca Anglani1, Dorella Del Prete1


1 Kidney histomorphology and molecular biology laboratory, Department of Medicine, University of Padua, Italy,
2 Nephrology Service, Hospital Británico de Buenos Aires, Argentina,
3 Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Italy,
4 Pathology service, Hospital Británico de Buenos Aires, Argentina.

10.15-10.30
De novo expression of tetraspanin CD9 commands invasive migration and proliferation of parietal epithelial cells and extracapillary glomerulopathies progression
Hélène Lazareth1,2,3 ¶, Carole Henique 1,4* ¶, Olivia Lenoir1 ¶, Victor G Puelles5,6 ¶, Martin Flamant7, Guillaume Bollée1, Fabian Braun6, Tobias B. Huber6, Dominique Nochy8, Patrick Bruneval8, Laurent Mesnard8, Eric Thervet1,3, Alexandre Karras1,3 &, François Le Naour10 &, Eric Rubinstein10 &, Claude Boucheix10 &, Antigoni Alexandrou2 &&, Marcus J Moeller5 &, Cédric Bouzigues2, Pierre-Louis Tharaux1,3 *

¶ or &: participated equally to the work


1 Paris Cardiovascular Centre (PARCC), Inserm U970, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
2 Laboratoire d’Optique et Biosciences, Ecole polytechnique, Palaiseau, France.
3 Renal Division, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris and Paris Descartes University, Paris, France.
4 Institut Mondor de Recherche Biomédicale, Inserm U955, Université Paris Est Créteil, Créteil, Paris.
5 Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
6 Department of Medicine III, Faculty of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
7 Xavier Bichat University Hospital, Paris Diderot University.
8 Department of Pathology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
9 Critical Care Nephrology and Kidney Transplantation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Inserm UMRS1155, Pierre and Marie Curie University, Paris, France.
10 Inserm Unit 935, Paris-Sud University, Villejuif, France.

10.30-10.45
Protective role of podocyte-expressed STAT5 during glomerular disease
A. Niasse1, K. Louis1, A. Corchia1, H. Dobosziewicz1, S. Placier1, Yc Xu-Dubois1,
S. Vandermeersch1, E. Rondeau1,2, Lothar Hennighausen3, L. Mesnard1,2, Y. Luque1,2


1 Inserm Unité UMR-S 1155, Paris, France.
2
Urgences Néphrologiques et Transplantabon rénale, Hôpital Tenon, Assistance Publique – Hôpitaux de Paris, Paris, France.
3
Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

10.45-11.15Coffee Break
11.15-11.45Scientific Session 7
Chairs: Ute Raffetseder and Karlhans Endlich
11.15-11.45Seventh plenary talk
Peter Boor
Imaging of renal fibrosis: an update
12.00 -15.30Cultural Events
12.00-13.30Presentation of the excavation of Nemea by Professor Stephen Miller (Professor of Classical Archeology, University of California, Berkeley) and visit to Nemea site
13.30-15.30Visit to the Semeli Winery of modern Nemea (includes lunch and wine tasting)
15.30-17.00Free time
17.00-19.00Scientific Session 8

 

17.00-18.30 Parallel discussion sessions:

Session 8.1: What modern nephrologists expect from basic science
Chairs-Discussion leaders: Bernard Banas and Josef Pfeilschifter

Session 8.2: Podocytes and parietal epithelial cells of the glomerulus: unresolved issues
Chairs-Discussion leaders: Nicole Endlich, Pierre-Louis Tharaux, Sanna Lehtonen

18.30-19.00Business Meeting Chairs: Malcolm Davies and Aris Charonis

  • Short presentation of the Journal NEPHRON
  • Discussion on the format of the current meeting
  • Decision on the site of the next (the 32nd) ERCSG meeting
20.00-24.00 Goodbye dinner and musical event
Sunday March 31st (beware of time change!)
07.00-08.30Breakfast
06.00-…Departure of participants

Contact Person:
Aris Charonis
E-mail : acharonis@bioacademy.gr

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